Protein Details: Potassium voltage-gated channel subfamily V member 1

Protein ID

ICDB_Pro_1022

Protein Name

Potassium voltage-gated channel subfamily V member 1

Gene Name

KCNV1

Organism

Mesocricetus auratus (Golden hamster)

Length

504 amino acids

AlphaFoldDB

AF-Q60565-F1-model_v4.pdb

Function

Potassium channel subunit that does not form functional channels by itself. Modulates KCNB1 and KCNB2 channel activity by shifting the threshold for inactivation to more negative values and by slowing the rate of inactivation. Can down-regulate the channel activity of KCNB1; KCNB2; KCNC4 and KCND1; possibly by trapping them in intracellular membranes (By similarity)

Sequence

MDLSPRNRPLLESSSLDSGGSLSSLDSSVFCSEGEGEPLALGDCLTVNVGGSRFVLSQQALSCFPHTRLGKLAVVVASYRRLGALAAAPSPLELCDDANPVDNEYFFDRSSQAFRYVLHYYRTGRLHVMEQLCALSFLQEIQYWGIDELSIDSCCRDRYFRRKELSETLDFKKDTDDQESQHESEQDFSQGPCPTVRQKLWDILEKPGSSTAARIFGVISIIFVAVSIVNMALMSAELSWLNLQLLEILEYVCISWFTGEFILRFLCVKDRCRFLRKVPNIIDLLAILPFYITLLVESLSGSHTTQELENVGRLVQVLRLLRALRMLKLGRHSTGLRSLGMTITQCYEEVGLLLLFLSVGISIFSTIEYFAEQSIPDTTFTSVPCAWWWATTSMTTVGYGDIRPDTTTGKIVAFMCILSGILVLALPIAIINDRFSACYFTLKLKEAAVRQREALKKLTKNIATDSYISVNLRDVYARSIMEMLRLKGRERASTRSSGGDDFWF

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Location

Detected in brain; throughout layers II; IV and VI of the brain cortex. Detected in cerebellum and hippocampus; in the granule cell layer; Purkinje cell layer; pyramidal cell layer and dentate gyrus. Detected at lower levels in olfactory bulb; amygdala; thalamus; hypothalamus; midbrain and brainstem.

DOI ID

10.1002/j.1460-2075.1996.tb00697.x

RefSeq

NP_001268571.1; XP_012970704.1